GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3749237 | 1 | rs4768 | chr3:49758764 | CCDC36 | chr3:49235861-49295537:+ | 0.18 | 3.78 | 0.000179 | Resting heart rate |
| THCA | cis | rs3749237 | 1 | rs4768 | chr3:49758764 | RBM6 | chr3:49977592-50137484:+ | -0.14 | -4.19 | 3.28E-5 | Resting heart rate |
| THCA | cis | rs11169552 | 1 | rs4768866 | chr12:51156580 | DIP2B | chr12:50898768-51142448:+ | -0.23 | -8.31 | 1.01E-15 | Colorectal cancer |
| THCA | cis | rs12304921 | 1 | rs4768942 | chr12:51355701 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.8 | 2.17E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs4768942 | chr12:51355701 | TFCP2 | chr12:51488608-51566917:- | -0.21 | -4.35 | 1.68E-5 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs4768943 | chr12:51355939 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.74 | 2.88E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs4768943 | chr12:51355939 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.29 | 2.15E-5 | Type 2 diabetes |
| THCA | cis | rs683250 | 1 | rs477046 | chr11:83324190 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 4 | 7.34E-5 | Subcortical brain region volumes |
| THCA | cis | rs76248362 | 1 | rs4770506 | chr13:24434703 | C1QTNF9B | chr13:24465238-24471641:- | -0.35 | -3.53 | 0.00045 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs76248362 | 1 | rs4770507 | chr13:24434744 | C1QTNF9B | chr13:24465238-24471641:- | -0.35 | -3.53 | 0.00045 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs76248362 | 1 | rs4770509 | chr13:24438643 | C1QTNF9B | chr13:24465238-24471641:- | -0.35 | -3.6 | 0.000357 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs2119480 | 1 | rs4771705 | chr13:111321757 | CARS2 | chr13:111293757-111365950:- | 0.21 | 6.05 | 2.86E-9 | Diastolic blood pressure |
| THCA | cis | rs1926657 | 1 | rs4771907 | chr13:95868980 | ABCC4 | chr13:95672084-95953687:- | -0.19 | -3.62 | 0.000328 | Breast cancer |
| THCA | cis | rs1926657 | 1 | rs4771908 | chr13:95872411 | ABCC4 | chr13:95672084-95953687:- | -0.18 | -3.47 | 0.000558 | Breast cancer |
| THCA | cis | rs9561329 | 1 | rs4773747 | chr13:94075872 | GPC6 | chr13:93879078-95060267:+ | -0.27 | -3.61 | 0.000336 | Neuroticism |